FaCD Online Syndrome Fact Sheet

Last updated: 21 Feb 2008

Name: Dermatofibromas, Familial Clustering of

Synonym: Familial Dermatofibroma; Multiple Fibrous Histiocytomas, Familial Clustering of

Mode of Inheritance: AD?

Tumor features

dermatofibroma (dermal fibrous histiocytoma)

Tumor features (possible)

malignant fibrous histiocytoma of the lung

Comment

Multiple fibrous histiocytoma of the skin (dermatofibromas) were diagnosed in a 47-year-old male (onset in his teens) as well as a malignant fibrous histiocytoma of the lung. Four of his five sons were also diagnosed with multiple dermatofibromas. The father, brothers and a sister of the proband had a history of skin nodules (no histology).[1]. Another familial case has been reported as well[2].

References

[1] Roberts JT, Byrne EH, Rosenthal D. Familial variant of dermatofibroma with malignancy in the proband. Arch Dermatol 1981; 117(1):12-15.
[2] Samlaska C, Bennion S. Eruptive dermatofibromas in a kindred. Cutis; cutaneous medicine for the practitioner 2002; 69(3):187-8, 190.