FaCD Online Syndrome Fact Sheet

Last updated: 29 May 2003

Name: Hodgkin's Disease, Multiple Primary Malignancies in Patients with

Tumor features

breast cancer
colon cancer
gastric cancer
Hodgkin disease (Hodgkin's lymphoma)
leukemia, acute lymphoblastic (ALL)
leukemia, acute myeloid (AML, incl. ANLL)
leukemia, chronic myeloid (CML)
lung/bronchial cancer
non-Hodgkin lymphoma
sarcoma
thyroid cancer

Non-tumor features (possible)

increased sister chromatid exchange

Comment

Patients treated for Hodgkin's disease have an increased risk to develop leukemia (especially AML (ANLL), much less often ALL and CML), non-Hodgkin lymphoma and solid tumors, in particular lung cancer, breast cancer, stomach cancer, thyroid cancer, colon cancer and sarcomas.[1-14]. Most of these tumors are probably therapy-related.
Baseline sister chromatid exchange frequencies might be a useful biomarker for identifying HD patients at increased risk of developing second cancers[15]

General aspects to consider with respect to multiple primary tumors:
- Shared genetic (immune response, metabolic/hormonal/DNA-repair pathways) or non-genetic (chemical carcinogens, radiation, viruses, life-style) risk factors
- Therapy (radiation, chemotherapy, hormonal) related effects
- Possible bias because of increased surveillance and autopsy findings.

References

[1] Metayer C, Lynch CF, Clarke EA, Glimelius B, Storm H, Pukkala E, Joensuu T, van Leeuwen FE, van't Veer MB, Curtis RE, Holowaty EJ, Andersson M, Wiklund T, Gospodarowicz M, Travis LB. Second cancers among long-term survivors of Hodgkin's disease diagnosed in childhood and adolescence. J Clin Oncol 2000; 18(12):2435-2443.
[2] Foss AA, Andersen A, Nome O, Jacobsen AB, Holte H, Foss AJ, Kvaloy S. Long-term risk of second malignancy after treatment of Hodgkin's disease: the influence of treatment, age and follow-up time. Ann Oncol 2002; 13(11):1786-1791.
[3] Beaty O, Hudson MM, Greenwald C, Luo XL, Fang L, Wilimas JA, Thompson EI, Kun LE, Pratt CB. Subsequent malignancies in children and adolescents after treatment for Hodgkin's disease. J Clin Oncol 1995; 13:603-609.
[4] Bhatia S, Robison LL, Oberlin O, Greenberg M, Bunin G, Fossati-Bellani F, Meadows AT. Breast cancer and other second neoplasms after childhood Hodgkin's disease. N Engl J Med 1996; 334:745-751.
[5] Dores GM, Metayer C, Curtis RE, Lynch CF, Clarke EA, Glimelius B, Storm H, Pukkala E, van Leeuwen FE, Holowaty EJ, Andersson M, Wiklund T, Joensuu T, van't Veer MB, Stovall M, Gospodarowicz M, Travis LB. Second malignant neoplasms among long-term survivors of Hodgkin's disease: a population-based evaluation over 25 years. J Clin Oncol 2002; 20(16):3484-3494.
[6] Varady E, Deak B, Molnar ZS, Rosta A, Schneider T, Esik O, Eckhardt S. Second malignancies after treatment for Hodgkin's disease. Leuk Lymphoma 2001; 42(6):1275-1281.
[7] Travis LB, Gospodarowicz M, Curtis RE, Clarke EA, Andersson M, Glimelius B, Joensuu T, Lynch CF, van Leeuwen FE, Holowaty E, Storm H, Glimelius I, Pukkala E, Stovall M, Fraumeni JF, Jr., Boice JD, Jr., Gilbert E. Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease. J Natl Cancer Inst 2002; 94(3):182-192.
[8] Rueffer U, Josting A, Franklin J, May M, Sieber M, Breuer K, Engert A, Diehl V. Non-Hodgkin's lymphoma after primary Hodgkin's disease in the German Hodgkin's Lymphoma Study Group: incidence, treatment, and prognosis. J Clin Oncol 2001; 19(7):2026-2032.
[9] Swerdlow AJ, Schoemaker MJ, Allerton R, Horwich A, Barber JA, Cunningham D, Lister TA, Rohatiner AZ, Vaughan HG, Williams MV, Linch DC. Lung cancer after Hodgkin's disease: a nested case-control study of the relation to treatment. J Clin Oncol 2001; 19(6):1610-1618.
[10] Clemons M, Loijens L, Goss P. Breast cancer risk following irradiation for Hodgkin's disease. Cancer Treat Rev 2000; 26(4):291-302.
[11] Green DM, Hyland A, Barcos MP, Reynolds JA, Lee RJ, Hall BC, Zevon MA. Second malignant neoplasms after treatment for Hodgkin's disease in childhood or adolescence. J Clin Oncol 2000; 18(7):1492-1499.
[12] Swerdlow AJ, Barber JA, Hudson GV, Cunningham D, Gupta RK, Hancock BW, Horwich A, Lister TA, Linch DC. Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 2000; 18(3):498-509.
[13] Nyandoto P, Muhonen T, Joensuu H. Second cancer among long-term survivors from Hodgkin's disease. Int J Radiat Oncol Biol Phys 1998; 42(2):373-378.
[14] Travis LB, Curtis RE, Bennett WP, Hankey BF, Travis WD, Boice JD. Lung cancer after Hodgkin's disease. J Natl Cancer Inst 1995; 87(17):1324-1327.
[15] Strom SS, Gu Y, Sigurdson AJ, Bailey NM, Amos CI, Spitz MR, Rodriguez MA, Liang JC. Chromosome breaks and sister chromatid exchange as predictors of second cancers in Hodgkin's disease. Leuk Lymphoma 1998; 28(5-6):561-566.