FaCD Online Syndrome Fact Sheet

Last updated: 10 May 2011

Name: Non-Hodgkin's lymphoma, Auricular Hypoplasia, Ligneous Conjunctivitis and Juvenile Colloid Milium

Mode of Inheritance: spor? AR?

Tumor features (possible)

non-Hodgkin lymphoma

Non-tumor features

conjunctivitis, ligneous
juvenile colloid milium

Comment

Kavak et al[1] reported a 19-year-old man from consanguineous parents, who was diagnosed with mucosal and skin deposits of an amyloid-like homogeneous material, non-Hodgkin's lymphoma (at the age of 11 years) and congenital unilateral auricular hypoplasia. The authors speculated whether or not this combination might represent a new syndrome. Based on the literature and their own experience, Schuster et al[2] suggested that the simultaneous occurrence of a lymphoma as well as ligneous conjunctivitis and juvenile colloid milium is most likely to be coincidental.

References

[1] Kavak A, Kaya M, Alper M, Cam M, Büyükbabani N, Bilen A, Silan F. Non-Hodgkin's lymphoma and auricular hypoplasia: associated with juvenile colloid milium or ligneous conjunctivitis? J Eur Acad Dermatol Venereol. 2005 May;19(3):348-51.
[2] Schuster V, Tefs K, Hügle B. Juvenile colloid milium and ligneous conjunctivitis are caused by severe hypoplasminogenemia--no evidence for causal relationship to non-Hodgkin's lymphoma.J Eur Acad Dermatol Venereol. 2006 Nov;20(10):1368.