FaCD Online Syndrome Fact Sheet

Last updated: 05 Apr 2008

Name: Flegel's Disease

Synonym: Hyperkeratosis Lenticularis Perstans

Mode of Inheritance: AD

OMIM number: 144150  

Tumor features (possible)

skin cancer, basal cell
skin cancer, squamous cell

Non-tumor features

hyperkeratosis

Comment

This is a rare disorder characterized by the occurrence of multiple small hyperkeratotic skin lesions on arms, legs and pinnae[1]. An association with basal and squamous cell skin cancer has been suggested[2]. A relation with internal malignancies has been reported as well, however, details on these cases (e.g. all old age at diagnosis ?) were limited[3].

References

[1] Price ML, Jones EW, MacDonald DM. A clinicopathological study of Flegel's disease (hyperkeratosis lenticularis perstans). Br J Dermatol 1987; 116(5):681-691.
[2] Beveridge GW, Langlands AO. Familial hyperkeratosis lenticularis perstans associated with tumours of the skin. Br J Dermatol 1973; 88(5):453-458.
[3] Ishibashi A, Tsuboi R, Fujita K. Familial hyperkeratosis lenticularis perstans. Associated with cancers of the digestive organs. J Dermatol 1984; 11(4):407-409.