FaCD Online Syndrome Fact Sheet

Last updated: 14 May 2010

Name: Alcohol intake

Tumor features

breast cancer
esophageal cancer
laryngeal cancer
leukemia, acute
leukemia, acute myeloid (AML, incl. ANLL)
lung/bronchial cancer
oral cancer
vaginal cancer

Tumor features (possible)

cervical cancer
colorectal cancer
non-Hodgkin lymphoma
pancreatic adenocarcinoma

Non-tumor features

liver cirrhosis


Increased risk for a range of tumors has been associated with alcoholism / alcohol intake: oropharyngeal and esophageal cancer, laryngeal cancer, hepatocellular cancer, breast cancer,(colo)rectal cancer and cervical (also carcinoma in situ) and vaginal cancer.[1-12]. Increased pancreatic cancer has been reported in association with heavy ethanol intake[13,15]. Alcohol consumption has been suggested to increase the risk of non-Hodgkin's lymphoma in men with a family history of hematolymphoproliferative cancer[14]. Case-control studies indicate that maternal alcohol consumption during pregnancy is associated with a significantly increased risk of AML in young children[16] (discussing the genetic component of alcoholism & alcohol metabolism is beyond the scope of FaCD)


[1] Longnecker MP. Alcohol consumption and risk of cancer in humans: An overview. Alcohol 1995; 12:87-96.
[2] Sigvardsson S, Hardell L, Przybeck TR, Cloninger R. Increased cancer risk among Swedish female alcoholics. Epidemiology 1996; 7(2):140-143.
[3] Talamini G, Bassi C, Falconi M, Sartori N, Salvia R, Rigo L, Castagnini A, Di F, V, Frulloni L, Bovo P, Vaona B, Angelini G, Vantini I, Cavallini G, Pederzoli P. Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer. Dig Dis Sci 1999; 44(7):1303-1311.
[4] Weiderpass E, Ye W, Tamimi R, Trichopolous D, Nyren O, Vainio H, Adami HO. Alcoholism and risk for cancer of the cervix uteri, vagina, and vulva. Cancer Epidemiol Biomarkers Prev 2001; 10(8):899-901.
[5] Ye W, Lagergren J, Weiderpass E, Nyren O, Adami HO, Ekbom A. Alcohol abuse and the risk of pancreatic cancer. Gut 2002; 51(2):236-239.
[6] Boonyaphiphat P, Thongsuksai P, Sriplung H, Puttawibul P. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Lett 2002; 186(2):193.
[7] Vachon CM, Cerhan JR, Vierkant RA, Sellers TA. Investigation of an interaction of alcohol intake and family history on breast cancer risk in the Minnesota breast cancer family study. Cancer 2001; 92(2):240-248.
[8] Adami HO, Mclaughlin JK, Hsing AW, Wolk A, Ekbom A, Holmberg L, Persson I. Alcoholism and cancer risk: a population-based cohort study. Cancer Causes Control 1992; 3(5):419-425.
[9] Garavello W, Bosetti C, Gallus S, Maso LD, Negri E, Franceschi S, La Vecchia C. Type of alcoholic beverage and the risk of laryngeal cancer. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2006; 15(1):69-73.
[10] Altieri A, Bosetti C, Gallus S, Franceschi S, Dal Maso L, Talamini R, Levi F, Negri E, Rodriguez T, La Vecchia C. Wine, beer and spirits and risk of oral and pharyngeal cancer: a case-control study from Italy and Switzerland. Oral oncology 2004; 40(9):904-9.
[11] Weikert C, Dietrich T, Boeing H, Bergmann MM, Boutron-Ruault MC, Clavel-Chapelon F, Allen N, Key T, Lund E, Olsen A, Tjønneland A, Overvad K, Rohrmann S, Linseisen J, Pischon T, Trichopoulou A, Weinehall L, Johansson I, Sánchez MJ, Agudo A, Barricarte A, Amiano P, Chirlaque MD, Quirós JR, Wirfalt E, Peeters PH, Bueno-de-Mesquita HB, Vrieling A, Pala V, Palli D, Vineis P, Tumino R, Panico S, Bingham S, Khaw KT, Norat T, Jenab M, Ferrari P, Slimani N, Riboli E. Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Int J Cancer. 2009 Feb 23;125(2):406-412
[12] Ferrari P, Jenab M, Norat T, Moskal A, Slimani N, Olsen A, Tjønneland A, Overvad K, Jensen MK, Boutron-Ruault MC, Clavel-Chapelon F, Morois S, Rohrmann S, Linseisen J, Boeing H, Bergmann M, Kontopoulou D, Trichopoulou A, Kassapa C, Masala G, Krogh V, Vineis P, Panico S, Tumino R, van Gils CH, Peeters P, Bueno-de-Mesquita HB, Ocké MC, Skeie G, Lund E, Agudo A, Ardanaz E, López DC, Sanchez MJ, Quirós JR, Amiano P, Berglund G, Manjer J, Palmqvist R, Van Guelpen B, Allen N, Key T, Bingham S, Mazuir M, Boffetta P, Kaaks R, Riboli E. Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer. 2007 Nov 1;121(9):2065-72.
[13] Rohrmann S, Linseisen J, Vrieling A, Boffetta P, Stolzenberg-Solomon RZ, Lowenfels AB, Jensen MK, Overvad K, Olsen A, Tjonneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Misirli G, Lagiou P, Trichopoulou A, Kaaks R, Bergmann MM, Boeing H, Bingham S, Khaw KT, Allen N, Roddam A, Palli D, Pala V, Panico S, Tumino R, Vineis P, Peeters PH, Hjartåker A, Lund E, Redondo Cornejo ML, Agudo A, Arriola L, Sánchez MJ, Tormo MJ, Barricarte Gurrea A, Lindkvist B, Manjer J, Johansson I, Ye W, Slimani N, Duell EJ, Jenab M, Michaud DS, Mouw T, Riboli E, Bueno-de-Mesquita HB. Ethanol intake and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).Cancer Causes Control 2009 Jul;20(5):785-94.
[14] Chiu BCH, Weisenburger DD, Cantor KP, Zahm SH, Holmes F, Burmeister LF, Blair A. Alcohol consumption, family history of hematolymphoproliferative cancer, and the risk of non-Hodgkin's lymphoma in men. Ann Epidemiol 2002; 12(5):309-315.
[15] Michaud DS, Vrieling A, Jiao L, Mendelsohn JB, Steplowski E, Lynch SM, Wactawski-Wende J, Arslan AA, Bas Bueno-de-Mesquita H, Fuchs CS, Gross M, Helzlsouer K, Jacobs EJ, Lacroix A, Petersen G, Zheng W, Allen N, Ammundadottir L, Bergmann MM, Boffetta P, Buring JE, Canzian F, Chanock SJ, Clavel-Chapelon F, Clipp S, Freiberg MS, Michael Gaziano J, Giovannucci EL, Hankinson S, Hartge P, Hoover RN, Allan Hubbell F, Hunter DJ, Hutchinson A, Jacobs K, Kooperberg C, Kraft P, Manjer J, Navarro C, Peeters PH, Shu XO, Stevens V, Thomas G, Tjønneland A, Tobias GS, Trichopoulos D, Tumino R, Vineis P, Virtamo J, Wallace R, Wolpin BM, Yu K, Zeleniuch-Jacquotte A, Stolzenberg-Solomon RZ. Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan). Cancer Causes Control. 2010 Apr 7. [epub advanced of print]
[16] Latino-Martel P, Chan DS, Druesne-Pecollo N, Barrandon E, Hercberg S, Norat T. Maternal alcohol consumption during pregnancy and risk of childhood leukemia: systematic review and meta-analysis.Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1238-60.