FaCD Online Syndrome Fact Sheet

Last updated: 30 Mar 2008

Name: Chronic Obstructive Pulmonary Disease

Synonym: COPD

Mode of Inheritance: Multifact

OMIM number: 606963  

Tumor features

lung/bronchial cancer

Non-tumor features



COPD increases the risk to develop lung cancer by two-fold[1-3]. There may be familial environmental as well as genetic risk factors shared by lung cancer and COPD[4]. (genes too many to list)


[1] Sin DD, Man SP. Impact of cancers and cardiovascular diseases in chronic obstructive pulmonary disease. Current opinion in pulmonary medicine 2008; 14(2):115-121.
[2] Nakayama M, Satoh H, Sekizawa K. Risk of cancers in COPD patients. Chest 2003; 123(5):1775-6.
[3] Kurishima K, Satoh H, Ishikawa H, Yamashita YT, Homma T, Ohtsuka M, Sekizawa K. Lung cancer patients with chronic obstructive pulmonary disease. Oncology reports 2001 Jan-Feb; 8(1):63-5.
[4] Schwartz AG, Ruckdeschel JC. Familial lung cancer: genetic susceptibility and relationship to chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 2006; 173(1):16-22.