FaCD Online Syndrome Fact Sheet

Last updated: 21 Mar 2008

Name: CLOVE syndrome

Synonym: Congenital Lipomatous Overgrowth, Vascular Malformations and Epidermal Nevi

Mode of Inheritance: spor / mosaic

Tumor features

lipoma

Non-tumor features

arteriovenous malformation
gigantism/overgrowth
limb asymmetry
nevi
regional overgrowth/hypertrophy of the body

Comment

Sapp et al reported seven patients with progressive, complex, and mixed truncal vascular malformations, dysregulated adipose tissue, varying degrees of scoliosis, and enlarged bony structures without progressive bony overgrowth. They have named this condition congenital lipomatous overgrowth, vascular malformations, and epidermal nevi[1]. They argue that this disorder is distinct from Proteus syndrome.

References

[1] Sapp JC, Turner JT, van de Kamp JM, van Dijk FS, Lowry RB, Biesecker LG. Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients. American journal of medical genetics. Part A 2007; 143(24):2944-58.